Live Webinar

SYMPOSIUM 10: Sleep and dementia risk: identifying involved sleep characteristics and mechanisms

Event Details

SYMPOSIUM 10: Sleep and dementia risk: identifying involved sleep characteristics and mechanisms

CHAIRPERSON: Andrée-Ann Baril1

PRESENTERS: Andrée-Ann Baril1; Andrew Lim2; Claire André3; Matthew Pase4

AFFILIATIONS: 1 Douglas Mental Health Institute, McGill University; 2 Sunnybrook Health Sciences Centre, University of Toronto; 3 Center for Advanced Research in Sleep Medicine, Université de Montréal; 4 Turner Institute for Brain and Mental Health, Monash University

DESCRIPTION: Sleep disturbances emerged in recent years as a risk factor for neurodegeneration and cognitive decline. Because dementia and Alzheimer’s disease remain incurable, understanding how sleep disturbances might contribute to neurodegenerative processes represent an important opportunity to modify the disease trajectory. In this symposium, we will highlight the epidemiological association between incident Alzheimer’s disease dementia and sleep disturbances. How specific sleep stages, sleep fragmentation and sleep disorders associate with dementia risk will be discussed. To explore further explore the role of sleep disturbances in the development of neurodegenerative diseases, we will discuss key mechanistic hypotheses. We will discuss how sleep characteristics are associated with neurodegenerative pathology. Indeed, this program will address how neuroimaging biomarkers, commonly used within the dementia field of research, have furthered our understanding of the processes ongoing in individuals with sleep disturbances, and especially sleep apnea. We will also address the interplay between low-grade chronic inflammation, sleep and neurodegeneration. This program encompasses fields of neurology, epidemiology, dementia, sleep medicine, immune response and biomarkers.

LEARNING OBJECTIVES:

  1. Identify sleep characteristics that are associated with a higher dementia risk
  2. Recognize which sleep disturbances can impact Alzheimer’s disease pathological processes
  3. Understand the role of inflammation in the sleep-dementia relationship